The Drug COCAINE Effects!?
Question by Fahad G: The drug COCAINE effects!?
The drug cocaine in addition to blocking ion channels, also blocks catecholamine reuptake. How would this transport disruption lead to many of the drug effects seen in users?
Anyone know? Please help. Thanks in advance:)
Best answer:
Answer by betty
that is a good question
Answer by Steph
Cocaine inhibits the Na+/Dopamine(A catecholamine) antiporter, which uses the ion gradient of sodium to transport Dopamine back into the presynaptic cell. Inhibition of this antiporter will cause the dopamine to be present in the synaptic cleft for a longer period of time, enhancing its effect.
Dopamine is a neurotransmitter used in the central nervous system, and it’s responsible for the sensations of pleasure and extasy we feel. So, enhancing those signals will make you feel really good.